C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/47 (2006.01) C12N 9/24 (2006.01) C12N 15/56 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2094922
2094922 9207936 PCTABS00013 The present invention involves the production of human .alpha.-GalNAc by cloning and expressing the .alpha.-GalNAc coding sequence in eukaryotic host cell expressions systems. The eukaryotic expression systems, and in particular the mammalian host cell expression systems described herein provide for the appropriate co-translational and post-translation modifications required for proper processing, e.g., glycosylation, phosphorylation, etc. and sorting of the expression product so that an active enzyme is produced. The .alpha.-GalNAc produced in accordance with the invention may be used in the treatment of Schindler disease or for the hydrolysis of .alpha.-N-acetylgalactosaminyl moieties in various glycoconjugates.
Bishop David F.
Desnick Robert J.
Ioannou Yiannis A.
Wang Anne M.
Mount Sinai School Of Medicine Of The City University Of New Yor
Osler Hoskin & Harcourt Llp
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