C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/16 (2006.01) A61K 39/00 (2006.01) C07H 21/04 (2006.01) C07K 14/72 (2006.01) C07K 16/26 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/62 (2006.01) C12P 21/08 (2006.01) G01N 33/76 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2138999
The present invention relates to the GnRH-R genes and proteins. The DNA sequences disclosed herein may be engineered into expression systems designed for the production of GnRH-R and/or cell lines which express the GnRH-R and preferably respond to GnRH induced signal transduction. Such cell lines may advantageously be used for screening and identifying GnRH agonists and antagonists. In accordance with another aspect of the invention, the GnRH DNA, antisense oligonucleotide sequences, the GnRH expression products, and antibodies to such products may be used in the diagnosis and therapy of reproductive disorders associated with abnormal expression of the GnRH-R; e.g., overexpression, underexpression or expression or expression of a dysfunctional mutant receptor. Transgenic animals containing the GnRHR transgene may be used as animal models for the evaluation of GnRH analogs in vivo.
Mount Sinai School Of Medicine Of New York University
Osler Hoskin & Harcourt Llp
The Mount Sinai School Of Medicine Of The City University Of New
LandOfFree
Cloning and expression of gonadotropin-releasing hormone... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cloning and expression of gonadotropin-releasing hormone..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cloning and expression of gonadotropin-releasing hormone... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1506644