C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) C07H 21/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2143611
The present invention relates to the PUR protein, nucleotide sequences and expression vectors encoding PUR, and to methods for inhibiting PUR activity. The PUR proteins bind specifically to single stranded DNA in regions that coincide with eu- karyotic origin of replication, one of such is at the c-myc gene region shown in the figure; this indicates that PUR proteins may function to regulate DNA replication. Inhibitors of PUR activity may be used to treat hyperproliferative diseases such as cancer.
Bergemann Andrew D.
Johnson Edward M.
Mount Sinai School Of Medicine Of The City University Of New Yor
Osler Hoskin & Harcourt Llp
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