Cloning and identification of the motilin receptor

Details Cloning and identification of the motilin receptor Cloning and identification of the motilin receptor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07H 21/04 (2006.01) C07K 14/705 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2330251

The motilin receptor has been isolated and cloned, and nucleic acid sequences are given. Two splice variants have been identified. Also, assays for motilin receptor ligands are given. The identification of the cloned motilin receptor may be used to screen and identify compounds which bind to the receptor for use in a variety of gastric conditions, including gastric motility disorders.

Les auteurs ont isolé et cloné le récepteur de la motiline dont ils décrivent le séquençage des acides nucléiques. Les auteurs ont en outre identifié deux variantes à épissure. L'invention concerne ainsi des dosages de ligands du récepteur de la motiline. L'identification du récepteur cloné de la motiline permet également la recherche systématique ainsi que l'identification de composés qui se lient au récepteur, et ce, pour une grande diversités de pathologies gastriques, y compris les troubles de la motilité gastrique.

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