C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/37 (2006.01) C07K 1/36 (2006.01) C07K 14/755 (2006.01) C12N 1/21 (2006.01) C12N 15/70 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2077446
2077446 9113093 PCTABS00007 The subject invention provides non-glycosylated, biologically active polypeptides which comprise the vWF (von Willebrand Factor) GP1b binding domain. These polypeptides may be used to inhibit platelet adhesion and aggregation in the treatment of subjects with conditions such as cerebrovascular disorders and cardiovascular disorders. This invention also provides expression plasmids encoding these polypeptides as well as methods of producing by transforming a bacterial cell and recovering such polypeptides. In addition, the subject invention provides methods of treating and preventing cerebrovascular, cardiovascular and other disorders using these polypeptides to inhibit platelet aggregation.
Garfinkel Leonard
Richter Tamar
Bio-Technology General Corp.
Gowling Lafleur Henderson Llp
LandOfFree
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