Cloning and recombinant production of crf (corticotropin...

Details Cloning and recombinant production of crf (corticotropin... Cloning and recombinant production of crf (corticotropin...

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) A61K 39/395 (2006.01) C07H 21/00 (2006.01) C07K 14/72 (2006.01) C07K 16/28 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2162729

In accordance with the present invention there are provided novel G-protein-coupled receptor proteins (CRF-R) characterized by having sufficient binding affinity for corticotropin releasing factor (CRF) such that concentrations of 10 nM of CRF occupy 50 % of the binding sites of said receptor protein. Nucleic acid sequences encoding such receptors, assays employing same, as well as antibodies derived therefrom, are also disclosed. Invention CRF-Rs can be employed in a variety of ways, such as, for example, in bioassays, for production of antibodies thereto, in therapeutic compositions containing such proteins and/or antibodies.

L'invention décrit de nouvelles protéines réceptrices couplées à la protéine G (CRF-R), caractérisées en ce que leur affinité de liaison pour le facteur de libération de la corticotropine (CRF) est suffisante pour que des concentrations </= 10 nM de CRF occupent une proportion >/= 50 % des sites de liaison de ladite protéine réceptrice. Des séquences d'acide nucléique codant ces récepteurs et des dosages faisant appel à celles-ci sont également décrits, ainsi que des anticorps qui en sont dérivés. Les CRF-R selon l'invention peuvent être employés de diverses manières, par exemple dans des dosages biologiques, pour la production d'anticorps dirigés contre eux et dans des compositions thérapeutiques contenant ces protéines et/ou anticorps.

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