C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A61K 38/18 (2006.01) A61K 38/45 (2006.01) A61K 39/395 (2006.01) C07H 21/04 (2006.01) C07K 14/495 (2006.01) C07K 14/71 (2006.01) C07K 16/22 (2006.01) C12N 9/12 (2006.01) C12N 15/18 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2086327
2086327 9220793 PCTABS00017 In accordance with the present invention, there are provided novel receptor proteins characterized by having the following domains, reading from the N-terminal end of said protein: an extracellular, ligand-binding domain, a hydrophobic, trans-membrane domain, and an intracellular, receptor domain having serine kinase-like activity. The invention receptors optionally further comprise a second hydrophobic domain at the amino terminus thereof. The invention receptor proteins are further characterized by having sufficient binding affinity for at least one member of the activin/TGF-.beta. superfamily of polypeptide growth factors such that concentrations of Í 10 nM of said polypeptide growth factor occupy ã 50 % of the binding sites of said receptor protein. A presently preferred member of the invention superfamily of receptors binds specifically to activins, in preference to inhibins, transforming growth factor-.beta., and other non-activin-like proteins. DNA sequences encoding such receptors, assays employing same, as well as antibodies derived therefrom, are also disclosed.
Mathews Lawrence S.
Vale Wylie W.
Gowling Lafleur Henderson Llp
The Salk Institute For Biological Studies
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