Cloning b and t lymphocytes

Details Cloning b and t lymphocytes Cloning b and t lymphocytes

A - Human Necessities

01

K

A01K 67/00 (2006.01) A01K 67/027 (2006.01) A01K 67/033 (2006.01) C12N 15/00 (2006.01) C12N 15/85 (2006.01) C12N 15/87 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2473909

This invention includes methods for producing non-human mammals expressing monoclonal or oligoclonal B or T lymphocytes, as well as embryonic and hematopoietic stem cells that differentiate into monoclonal or oligoclonal B or T cells, using cloning by nuclear transfer with a B or T cell of interest as the nuclear donor cell.

Cette invention concerne des techniques de création de mammifères non humains qui expriment des lymphocytes B ou T monoclonaux ou oligoclonaux, ainsi que des cellules souches embryonnaires et hématopoïétiques qui se différencient en cellules B ou T monoclonales ou oligoclonales. Cette invention fait intervenir un clonage par transfert de noyau avec un cellule B ou T d'intérêt en tant que cellule donatrice de noyau.

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