Cloning, expression and uses for neurocan as a chondroitin...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 1/22 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/566 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2141600

Novel eukaryotic neurocan polypeptides, derivatives and analogs thereof and nucleic acid encoding therefor, which are useful for providing soluble, biologically active heterologous proteins in hosts, as well as hosts transformed with this nucleic acid and methods for producing soluble heterologous proteins in hosts using such molecules, and therapeutic uses thereof.

L'invention se rapporte à de nouveaux polypeptides "neurocan" eucaryotiques, à des dérivés et à des analogues de ceux-ci et à l'acide nucléique les codant, lesquels sont utilisés pour produire des protéines hétérologues, solubles, biologiquement actives, dans des hôtes, ainsi qu'à des hôtes transformés, à l'aide de cet acide nucléique, et à des procédés de production de protéines hétérologues solubles dans des hôtes au moyen de ces molécules, et aux utilisations thérapeutiques desdits polypeptides.

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