C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
260/227, 195/86,
C12N 15/70 (2006.01) C07H 17/08 (2006.01) C12N 9/10 (2006.01) C12N 9/88 (2006.01) C12N 15/10 (2006.01) C12N 15/52 (2006.01) C12N 15/76 (2006.01) C12P 17/18 (2006.01) C12P 19/62 (2006.01)
Patent
CA 2013524
There are disclosed plasmids containing DNA isolated from Streptomyces avermitilis, the microorganism which is used to prepare avermectin compounds, identified as pAT1, pVE650 pVE855, pVE859, pVE1446, pVE923, and pVE924 which contain the genetic information for the biosynthesis of the avermectins. Methods for the isolation of such plasmid and for the manipulation of the plasmids to alter the formation of the avermectin compound are also disclosed.
Gewain Keith M.
Macneil Douglas J.
Macneil Tanya
Paress Philip S.
Ruby Carolyn L.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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