Cloning of a novel g-protein coupled 7tm receptor

Details Cloning of a novel g-protein coupled 7tm receptor Cloning of a novel g-protein coupled 7tm receptor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2220856

HNHCI32 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HNHCI32 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertention; urinary retention; osteosporosis, angina pectoris; myocardial infaraction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

Polypeptides et polynucléotides HE8CH90, et mode de fabrication de ces polypeptides par la technique de l'ADN recombinant. Mode d'utilisation des polypeptides et des polynucléotides HE8CH90 dans la conception de protocoles pour traiter les infections, comme les infections bactériennes, fongiques, protozoaires et virales, notamment les infections causées par le VIH-1 ou le VIH-2; la douleur; les cancers; l'anorexie; la boulimie; l'asthme; la maladie de Parkinson; l'insuffisance cardiaque aiguë; l'hypotension; l'hypertension; la rétention urinaire; l'ostéoporose; l'angine de poitrine; l'infarctus du myocarde; les ulcères; les allergies; l'hypertrophie prostatique bénigne; et les troubles psychotiques et neurologiques, dont l'anxiété, la schizophrénie, le trouble bipolaire, le délire, la démence, le retard mental sévère et les dyskinésies, comme la maladie de Huntington ou la maladie de Gilles de la Tourette, entre autres, et épreuves diagnostiques pour ce genre d'affections.

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