C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/60 (2006.01) A61K 31/41 (2006.01) A61K 31/711 (2006.01) A61K 38/51 (2006.01) A61P 31/12 (2006.01) A61P 37/06 (2006.01) C12N 9/88 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2406390
Histidine ammonia lyase (HAL) isolated from Corynebacteriaceae can decrease serum histidine levels, induce accumulation of urocanic acid, and is not inhibited by L-histidinol. As a result, histidine ammonia lyases similar to the one isolated from Corynebacteriaceae are uniquely suitable for combination therapy with L-histidinol to treat histidine- and/or histamine-dependent pathologies, for example, infectious viruses, such as human Respiratory Syncytial Virus (RSV), Herpes Simplex Virus (HSV), and Human Immunodeficiency Virus (HIV), as well as cancers.
L'invention concerne une histidine ammoniac lyase (HAL) isolée à partir de Corynebacteriaceae, qui peut diminuer les taux sériques d'histidine, induire une accumulation d'acide urocanique, sans être inhibée par le L-histidinol. En conséquence, des types de lyase similaires à celle qui a été isolée se prêtent de façon unique à une thérapie de combinaison avec du L-histidinol, pour le traitement des pathologies dépendant de l'histidine et/ou de l'histamine, à savoir par exemple: virus infectieux comme le virus syncytial respiratoire humain, le virus herpès simplex et le virus de l'immunodéficience humaine, ainsi que les cancers.
Macallister Thomas
Roberts Joseph
Sethuraman Natarajan
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
University Of South Carolina
University Of South Carolina Research Foundation
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