Clostridial toxin activatable clostridial toxins

Details Clostridial toxin activatable clostridial toxins Clostridial toxin activatable clostridial toxins

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) C07K 14/33 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2610103

The specification discloses modified Clostridial toxins comprising a Clostridial toxin substrate cleavage site located within the di-chain loop region; polynucleotide molecules encoding such modified Clostridial toxins comprising a Clostridial toxin substrate cleavage site located in the di-chain loop region; and method of producing modified Clostridial toxins comprising Clostridial toxin substrate cleavage site located within the di-chain loop region.

La description concerne des toxines clostridiennes modifiées comprenant un site de clivage de substrat de toxine clostridienne situé à l'intérieur de la région de boucle à deux chaînes; des molécules polynucléotidiques codant pour de telles toxines clostridiennes modifiées comprenant un site de clivage de substrat de toxine clostridienne situé dans la région de boucle à deux chaînes; et un procédé de production de toxines clostridiennes modifiées comprenant un site de clivage de substrat de toxine clostridienne situé à l'intérieur de la région de boucle à deux chaînes.

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