Clostridial toxin netb

Details Clostridial toxin netb Clostridial toxin netb

C - Chemistry, Metallurgy

07

K

C07K 14/33 (2006.01) A01H 5/00 (2006.01) A23K 1/16 (2006.01) A23L 1/30 (2006.01) A23L 2/52 (2006.01) A61K 39/08 (2006.01) A61K 39/40 (2006.01) C07K 16/12 (2006.01) C12N 1/21 (2006.01) C12N 15/31 (2006.01)

Patent

CA 2689302

The present invention relates to a polypeptide based toxin that originates from Clostridium perfringens. The invention further relates to immunogenic compositions comprising the toxin and methods to vaccinate animals, for example chickens, such that they are less susceptible to clostridial diseases. Methods to determine whether an animal has been exposed to the toxin, polynucleotides encoding the toxin and attenuated bacteria that express a reduced or less active form of the toxin are also disclosed.

L'invention porte sur une toxine à base d'un polypeptide provenant du Clostridium perfringens. L'invention porte également sur des compositions immunogènes comprenant ladite toxine et sur des méthodes de vaccination d'animaux, par exemple des poulets, pour qu'ils soient moins sensibles aux maladies clostridiales. L'invention porte également: sur des méthodes permettant de déterminer si un animal a été exposé à la toxine, sur des polynucléotides codant pour la toxine et sur des bactéries atténuées exprimant une forme réduite ou moins active de la toxine.

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