A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/45 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01)
Patent
CA 2539694
Pharmaceutical compositions, each consisting of a cell-permeable fusion protein conjugate of a polypeptidic cell-membrane transport moiety and a Clostridium botulinum C3 exotransferase unit, or a functional analog thereof, are provided. The compositions are useful to prevent or inhibit uncontrolled proliferation, spreading, and migration of a metastatic neoplastic cell of a cancer in a mammal. The compositions can each effect or arrest combination of two or more of tumor cell proliferation, migration, angiogenesis, and metalloproteinase secretion.
L'invention concerne des compositions pharmaceutiques qui consistent en un conjugué de protéine de fusion perméable aux cellules d'un fragment de transport de membrane cellulaire polypeptidique et d'une unité exotransférase Clostridium botulinum C3, ou un analogue fonctionnel correspondant. Ces compositions sont utilisées pour prévenir ou inhiber la prolifération, la dissémination ou la migration incontrôlées des cellules métastatiques néoplasiques chez un mammifère. Ces compositions peuvent individuellement prévenir la prolifération et/ou la migration des cellules tumorales et/ou l'angiogenèse et/ou la sécrétion de métalloprotéinases.
Lasko Dana
Mckerracher Lisa
Bioaxone Therapeutique Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
LandOfFree
Clostridium botulinum c3 exotransferase compositions and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Clostridium botulinum c3 exotransferase compositions and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Clostridium botulinum c3 exotransferase compositions and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1961883