Clostridium perfringens vaccines

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/31 (2006.01) A61K 31/70 (2006.01) A61K 39/08 (2006.01) A61K 48/00 (2006.01) C07K 14/33 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2248707

The present invention provides proteins for use in vaccines which are capable of inducing protective antibodies directed against C. perfringens epsilon toxin when administered to animals or man and thereby providing prophylaxis or therapy against infection by C. perfringens epsilon toxin. Particularly the present invention provides proteins which are based upon the mature toxin of the clostridium perfringens epsilon toxin gene, but which have a mutation such that the amino acid at position 106 is different to the wild-type sequence and their use in vaccine compositions.

La présente invention se rapporte à des protéines destinées à être utilisées dans des vaccins qui sont capables d'induire des anticorps protecteurs dirigés contre la toxine epsilon de C. perfringens lorsque ces vaccins sont administrés à l'animal ou à l'homme, permettant par conséquent d'obtenir une prophylaxie ou une thérapie destinée à lutter contre l'infection due à la toxine epsilon C. perfringens. La présente invention se rapporte notamment à des protéines qui sont basées sur la toxine mature du gène de la toxine epsilon de clostridium perfringens, mais qui possède une mutation de sorte que l'acide aminé à la position 106 soit différent de la séquence de phénotype sauvage, ainsi qu'à l'utilisation de ces protéines dans des compositions de vaccins.

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