Closure of bacterial ghosts

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/03 (2006.01) A61K 9/127 (2006.01) A61K 9/50 (2006.01) A61K 35/74 (2006.01) A61K 39/00 (2006.01) A61K 39/02 (2006.01) A61K 48/00 (2006.01) C12N 1/06 (2006.01) C12N 1/20 (2006.01) C12N 1/21 (2006.01) C12N 15/02 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2423122

The invention relates to a method for production of closed bacterial ghosts, by means of vesicle membrane fusion and the corresponding bacterial ghosts. Active agents, for example, genetic material, cell components, pharmaceutical and agricultural agents and markers or dyes, may be packed in the closed bacterial ghosts. The metabolic functions and, optionally, reproductive viability of the bacterial ghosts can be re-established on packing genetic material in the bacterial ghost. The closed ghosts can find application in the medical, agricultural and biotechnology fields.

L'invention concerne un procédé de fabrication d'hôtes bactériens fermés au moyen d'une fusion membrane-vésicule, et les hôtes bactériens ainsi obtenus. Des agents actifs tels que par ex. de la matière génétique, des composantes cellulaires, des agents actifs pharmaceutiques et agricoles, ainsi que des substances de marquage et des colorants peuvent être intégrés dans les hôtes bactériens fermés. L'intégration de matière génétique dans les hôtes bactériens permet de rétablir des fonctions métaboliques et éventuellement la capacité de prolifération des cellules. Les hôtes fermés selon l'invention peuvent être employés en médecine, dans le domaine agraire, et en biotechnologie.

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