Cluster conjugates of drugs with antibodies

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 19/00 (2006.01) A61K 38/04 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) C07K 1/00 (2006.01) C07K 17/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2072824

X-8194 ABSTRACT Targeted drug conjugates which enable a large number of molecules of drug to be directed to a cell by a single molecule of antibody are provided. The invention also provides intermediates for the synthesis of such conjugates and cytotoxic drugs modified in accordance with the cluster concept of the invention.

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