C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 38/04 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) C07K 1/00 (2006.01) C07K 17/06 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2072824
X-8194 ABSTRACT Targeted drug conjugates which enable a large number of molecules of drug to be directed to a cell by a single molecule of antibody are provided. The invention also provides intermediates for the synthesis of such conjugates and cytotoxic drugs modified in accordance with the cluster concept of the invention.
Koppel Gary A.
Offord Robin E.
Rose Keith
Scott William L.
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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