A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/713 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) A61P 3/04 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2587319
Methods are provided for regulating adipogenesis and metabolic function in adipocytes by modulating the activity of chemokine-like receptor 1 (CMKLR1). Exemplary agents include those that modulate binding of CMKLR1 to a cognate ligand (e.g., chemerin), those that modulate signaling from CMKLR1, and those that modulate expression of either CMKLR1 or its cognate ligand in target cells. Methods are also provided for screening for agents that find use in regulating fat accumulation in a subject.
Butcher Eugene C.
Goralski Kerry
Mccarthy Tanya
Sinal Christopher
Zabel Brian A.
Dalhousie University
Fetherstonhaugh & Co.
The Board Of Trustees Of The Leland Stanford Junior University
The United States Government As Represented By The Department Of
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