Cng3b: a novel cyclic nucleotide-gated cation channel

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2408847

The invention provides isolated nucleic acid and amino acid sequences of CNG3B, antibodies to CNG3B, methods of detecting CNG3B, and methods of screening for modulators of cyclic nucleotide-gated ion channels using biologically active CNG3B. The invention further provides, in a computer system, a method of screening for mutations of human CNG3B genes as well as a method for identifying a three-dimensional structure of human CNG3B polypeptides.

L'invention concerne un acide nucléique isolé et des séquences d'acides aminés de CNG3B, des anticorps dirigés contre CNG3B, des méthodes de détection de CNG3B, ainsi que des méthodes de criblage de modulateurs de canaux ioniques dépendant de nucléotides cycliques à l'aide de CNG3B biologiquement actif. L'invention concerne également, dans un système informatique, une méthode de criblage de mutations des gènes CNG3B humains ainsi qu'une méthode d'identification d'une structure tridimensionnelle des polypeptides CNG3B humains.

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