C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 451/08 (2006.01) A61K 31/4375 (2006.01) A61P 25/00 (2006.01) C07D 451/14 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2647830
The invention relates to fused bicycloheterocycle substituted azabicyclic alkane derivatives of formula (I), or a pharmaceutically acceptable salt, ester, amid, or prodrug thereof, wherein n is 1, 2 or 3; A is N or N+-O-; R is hydrogen, alkyl, cycloalkylalkyl and arylalkyl; L is selected from the group consisting of O, S, and -N(Ra)-; Ar1 is a 6-membered aryl or 6 membered heteroaryl ring; and Ar2 is a bicyclic heteroaryl; and Ra is selected from the group consisting of hydrogen, alkyl and alkylcarbonyl; provided that if Ar1 is Formula (II), then L is O or S. Compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
L'invention concerne des dérivés d'alcanes azabicycliques substitués à bicyclohétérocycle fusionné, des compositions comprenant de tels composés, et des procédés de traitement de troubles et d'états pathologiques faisant intervenir de tels composés et de telles compositions.
Gopalakrishnan Murali
Ji Jianguo
Li Tao
Lynch Christopher L.
Abbott Laboratories
Torys Llp
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