Cns chloride modulation for treatment of pain

Details Cns chloride modulation for treatment of pain Cns chloride modulation for treatment of pain

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 31/18 (2006.01) A61K 31/472 (2006.01) A61K 31/553 (2006.01) A61K 49/00 (2006.01) A61K 51/04 (2006.01) A61P 29/00 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2524883

Methods and products for the attenuation or treatment of pain and the reduction of nociception are described. The methods and products are based on the modulation of CNS intracellular chloride levels. The methods and products may also relate to modulation of the activity and/or expression of a chloride transporter, such as the KCC2 potassium-chloride cotransporter. Also described herein are commercial packages and uses based on such modulation. Related methods for identifying or characterizing a compound for the treatment of pain, the reduction of nociception and the diagnosis and prognostication of pain are also described.

L'invention concerne des procédés et des produits pour atténuer ou traiter la douleur et pour réduire la nociception. Lesdits procédés et produits sont également fondés sur la modulation des teneurs en chlorure intracellulaire du SNC et ils permettent également la modulation de l'activité et/ou l'expression d'un transporteur de chlorure, tel que le cotransporteur de chlorure-potassium KCC2. L'invention concerne également des emballages commerciaux et des utilisations sur la base de ladite modulation ainsi que des procédés associés permettant d'identifier ou de caractériser un composé utilisé pour traiter la douleur, réduire la nociception et pour diagnostiquer et pronostiquer la douleur.

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