Cns pharmaceutical compositions and methods of use

A - Human Necessities – 61 – K

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A61K 31/137 (2006.01) A61K 31/09 (2006.01)

Patent

CA 2716080

The present invention is directed to CNS pharmaceutical compositions and methods of use. The pharmaceutical compositions comprise a CNS active agent and preferably at least two vagal neuromodulators, one of which is a mechanoreceptor stimulator. The vagal neuromodulators are preferably in an amount sufficient to reduce a side-effect of the CNS active agent. The invention further encompasses a method of reducing CNS active agent side- effects. The method typically comprises administering the CNS active agent to a patient; and administering at least two vagal neuromodulators to the patient so that at least one neuromodulator is administered or released after the CNS active agent is administered or released.

La présente invention concerne des compositions pharmaceutiques actives sur le SNC ainsi que des méthodes d'utilisation. Lesdites compositions pharmaceutiques comprennent un agent actif sur le SNC et de préférence au moins deux neuromodulateurs vagaux, un desquels étant un stimulateur de mécanorécepteurs. Les neuromodulateurs vagaux sont de préférence présents en quantité suffisante pour réduire un effet indésirable de l'agent actif sur le SNC. L'invention concerne en outre une méthode de réduction d'effets secondaires d'un agent actif sur le SNC. La méthode consiste généralement à administrer l'agent actif sur le SNC à un patient; et à administrer au moins deux neuromodulateurs vagaux au patient de sorte qu'au moins un neuromodulateur est administré ou libéré après que l'agent actif sur le SNC est administré ou libéré.

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