Co-administration of cg250 and il-2 or ifn-alpha for...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01) A61K 39/193 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2492057

A method for enhancing the therapeutic effect of cytokine treatment is disclosed. More specifically the present invention relates to a method for administering to a tumor patient a therapeutic dose of cytokine in combination with antibodies directed against the tumor associated antigen carbonic anhydrase IX (CAIX/G250/MN). The improved treatment method is characterized in a significantly reduced cytokine-related toxicity combined with potentiated effectiveness of anti-G250 antibody alone, resulting in a positive therapeutic response with respect to that observed with single anti-tumor agents alone.

L'invention a trait à une méthode permettant d'accentuer l'effet thérapeutique du traitement par cytokine. Plus précisément, la présente invention concerne une méthode destinée à administrer à un patient présentant une tumeur une dose thérapeutique de cytokine, en combinaison avec des anticorps dirigés contre l'anhydrase IX carbonique antigène associée à la tumeur (CAIX/G250/MN). La méthode de traitement améliorée est caractérisée par une toxicité liée à la cytokine sensiblement réduite, combinée à l'efficacité potentialisée de l'anticorps anti-G250 utilisé seul, ce qui donne lieu à une réponse thérapeutique positive, par rapport à la réponse observée avec des agents antitumoraux uniques utilisés seuls.

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