Co-crystals and pharmaceutical compositions comprising the same

Details Co-crystals and pharmaceutical compositions comprising the same Co-crystals and pharmaceutical compositions comprising the same

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/497 (2006.01) A61K 38/07 (2006.01) C07K 5/10 (2006.01)

Patent

CA 2679312

The invention relates to compositions and co-crystals each comprising VX-950 and a co-crystal former selected from the group consisting of 4-hydroxybenzoic acid, 4-amino salicylic acid, phenylalanine, threonline, tartaric acid, adipic acid, succinic acetate, proline, methyl 4-hydroxybenzoate, anthranilic acid, and d-Biotin. Also within the scope of this invention are methods of making and using the same.

L'invention concerne des compositions et des co-cristaux comprenant chacun VX-950 et un composé formant un co-cristal choisi dans le groupe constitué de l'acide 4-hydroxybenzoïque, l'acide 4-amino salicylique, la phénylalanine, la thréonine, l'acide tartrique, l'acide adipique, l'acétate succinique, la proline, le 4-hydrobenzoate de méthyle, l'acide anthranilique et la d-biotine. Des procédés de fabrication et d'utilisation de ceux-ci sont également dans la portée de la présente invention.

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