Co-crystals of tramadol and nsaids

Details Co-crystals of tramadol and nsaids Co-crystals of tramadol and nsaids

A - Human Necessities

61

K

A61K 31/135 (2006.01) A61K 31/192 (2006.01) A61P 25/04 (2006.01) A61P 29/00 (2006.01) C07C 59/64 (2006.01) C07C 217/74 (2006.01)

Patent

CA 2737754

The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain. In a preferred embodiment, the co-crystal is a co-crystal of (-) - tramadol and (S) -naproxen (1:2); (+) -tramadol and (R) -naproxen (1:2) or (rac) -tramadol-Hcl-celecoxib (1:1).

La présente invention concerne des co-cristaux de tramadol et des agents de formation de co-cristaux choisis parmi les AINS, des procédés de préparation de ceux-ci et leurs utilisations en tant que médicaments ou dans des formulations pharmaceutiques, plus particulièrement pour le traitement de la douleur. Dans un mode de réalisation préféré, le co-cristal est un co-cristal de (-)-tramadol et de (S)-naproxène (1/2) ; (+)-tramadol et (R)-naproxène (1/2) ou (rac)-tramadol-HCl-célécoxib (1/1).

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