Co-culture lymphoid tissue equivalent (lte) for an...

C - Chemistry – Metallurgy – 12 – N

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C12N 5/0781 (2010.01) A61K 39/395 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2659676

The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologies and other chemicals.

La présente invention concerne des procédés de préparation d'un système immunitaire artificiel. Ledit système immunitaire artificiel est constitué d'une culture cellulaire contenant des lymphocytes T, des lymphocytes B et des cellules dendritiques sensibilisées aux antigènes. Le système immunitaire artificiel de la présente invention peut être utilisé pour des tests in vitro de vaccins, d'adjuvants, de candidats d'immunothérapie, de produits cosmétiques, de médicaments, de processus biologiques et d'autres produits chimiques.

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