C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/06 (2006.01)
Patent
CA 2633775
The present invention relates to a combination of placental stem cells and stem or progenitor cells derived from a second source, wherein the combination shows improved engraftment as compared to placental stem cells or stem cells from a second source, alone. The combination is referred to as a combined stem cell population. The invention also provides in vitro and in vivo methods for identifying and producing combined stem cell populations, and models of engraftment. In accordance with the present invention, the placental stem cells may be combined with, e.g., umbilical cord blood-derived stem or progenitor cells, fetal or neonatal stem cells or progenitor cells, adult stem cells or progenitor cells, hematopoietic stem cells or progenitor cells, stem or progenitor cells derived from bone marrow, etc.
L'invention concerne une combinaison de cellules souches placentaires et de cellules souches ou progénitrices dérivées d'une seconde source. La combinaison montre une prise de greffe améliorée en comparaison avec des cellules souches placentaires ou des cellules souches provenant uniquement d'une seconde source. La combinaison est une population de cellules souches combinées. L'invention concerne également des procédés in vitro et in vivo permettant d'identifier et de produire des populations de cellules souches combinées, et des modèles de prise de greffe. Selon l'invention, les cellules souches placentaires peuvent être combinées avec, par exemple, une cellule dérivée du sang du cordon ombilical ou des cellules progénitrices, des cellules souches embryonnaires ou néonatales ou des cellules progénitrices, des cellules souches adultes ou des cellules progénitrices, des cellules souches hématopoïétiques ou des cellules progénitrices, des cellules souches ou progénitrices dérivées de la moelle osseuse, etc.
Heidaran Mohamad A.
Wang Jia-Lun
Ye Qian
Zeitlin Andrew
Anthrogenesis Corporation
Smart & Biggar
LandOfFree
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