Co-lyophilized complex of a nucleic acid vector and a...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2340416

The present invention relates generally to formulated nucleic acid vectors for gene therapy and more particularly to co-lyophilized formulations and methods of producing the same, wherein the co-lyophilized formulations are convenient and cost effective, protect the nucleic acids from chemical degradation and/or physical aggregation, and provide for relative ease of administration.

L'invention concerne généralement l'incorporation de plasmide dans une forme posologique classique, et notamment la production d'un complexe plasmide/polymère homogénéisé, dans un seul flacon, présentant les caractéristiques voulues. Elle porte encore sur des procédés de fabrication, de stockage et d'utilisation dudit complexe, décrits en détail ci-après. Lesdits produits et procédés permettent la production de complexes plus faciles à utiliser, plus économiques, protégés contre la dégradation chimique et/ou l'agrégation physique de ses composants et faciles à administrer. L'invention se rapporte ainsi, à un complexe plus efficace de libération de plasmide est formé, ainsi qu'à un procédé d'incorporation dudit plasmide dans une forme posologique classique.

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