A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4178 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 31/4174 (2006.01) A61K 9/20 (2006.01)
Patent
CA 2513729
The technical field of the invention relates to spray dried, co-precipitate amorphous losartan dosage forms that are stable over time and processes for their preparation. The processes stabilize the amorphous losartan. The process includes preparing an aqueous solution of losartan and one or more hydrophilic polymers; and spray drying the aqueous solution of losartan and one or more hydrophilic polymers to form a mixture. The amorphous losartan and one or more hydrophilic polymers are co-precipitated from the aqueous solution.
L'invention se rapporte à des posologies de losartan amorphe co-précipité séché par vaporisation stable dans le temps et à leurs traitements en vue de leur préparation. Les traitements stabilisent le losartan amorphe. Le traitement consiste à préparer une solution aqueuse de losartan et un ou plusieurs polymères hydrophiles ; puis à sécher par vaporisation la solution aqueuse de losartan et un ou plusieurs polymères hydrophiles afin d'obtenir un mélange. Le losartan amorphe et un ou plusieurs polymères hydrophiles sont co-précipités à partir de la solution aqueuse.
Kumar Pananchukunnath Manoj
Malik Rajiv
Manikandan Ramalingam
Nagaprasad Vishnubhotla
Singh Romi Barat
Deeth Williams Wall Llp
Ranbaxy Laboratories Limited
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