Coa-it and paf inhibitors

Details Coa-it and paf inhibitors Coa-it and paf inhibitors

C - Chemistry, Metallurgy

07

F

C07F 9/6506 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/4152 (2006.01) A61K 31/4164 (2006.01) A61K 31/4192 (2006.01) A61K 31/42 (2006.01) A61K 31/675 (2006.01) C07D 207/452 (2006.01) C07D 231/12 (2006.01) C07D 233/54 (2006.01) C07D 233/66 (2006.01) C07D 233/70 (2006.01) C07D 233/84 (2006.01) C07D 249/06 (2006.01) C07D 263/32 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2129897

Coenzyme A-independent transacylase is required for the release of free arachidonic acid and the production of arachidonic acid metabolites and platelet activation factor. Blocking of this enzyme inhibits the production of these inflammatory mediators and will be of therapeutic utility in a broad range of allergic and inflammatory diseases and disorders. Compounds are described herein which inhibit the action of CoA-IT and are therefore useful in the treatment of disease states caused thereby. The figure shows the effect of compound three on CoA-IT activity. In one embodiment, the compound is of formula (I)

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