Coadministration of transport protein with conjugated...

A - Human Necessities – 61 – K

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A61K 31/70 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2461705

Cobalamin transport proteins are administered in combination with cobalamin coupled to a diagnostic or pharmaceutically active agents to increase the extent of absorption of the diagnostic or pharmaceutically active agent. Cobalamin transport proteins include, but are not limited to intrinsic factor, transcobalamin I, transcobalamin II and transcobalamin III. The combination of the cobalamin or cobalamin derivative with the cobalamin transport protein provides enhanced cellular uptake.

L'invention concerne l'administration combinée de protéines de transport de cobalamine et de cobalamine couplée à des agents diagnostiques ou pharmaceutiques, qui permet d'augmenter le degré d'absorption de l'agent diagnostique ou pharmaceutique. Les protéines de transport de cobalamine comprennent notamment, mais non exclusivement, le facteur intrinsèque, la transcobalamine I, la transcobalamine II et la transcobalamine III. La combinaison de la cobalamine ou d'un dérivé de cobalamine avec la protéine de transport de cobalamine assure une absorption cellulaire améliorée.

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