Coagulation and fibrinolytic cascades modulator

Details Coagulation and fibrinolytic cascades modulator Coagulation and fibrinolytic cascades modulator

C - Chemistry, Metallurgy

07

K

C07K 14/745 (2006.01) C12Q 1/56 (2006.01)

Patent

CA 2600907

The invention provides a thromboplastin reagent comprising: tissue factor, a phospholipid and a polyphosphate that acts as a blocker of tissue factor pathway inhibitor (TFPI). Also provided are a composition for promoting clotting comprising polyphosphate, and a reagent for a clotting assay also comprising polyphosphate together with an activator of clotting. Methods for stopping or slowing wound bleeding and fibrinolysis using compositions comprising polyphosphate are also disclosed.

L'invention concerne un réactif de thromboplastine comprenant (i) du TF, (ii) un phospholipide, et (iii) un bloqueur polyP TFPI.

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