Coaster, a human coactivator of steroid receptors

Details Coaster, a human coactivator of steroid receptors Coaster, a human coactivator of steroid receptors

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2419981

The invention provides a protein having an amino acid sequence as in SEQ ID 7, 8, 11 or 12, similar proteins, naturally occurring variants and homologous functional equivalents thereof, as well as the use of a polynucleotide encoding such protein, for use in an assay and for use in a method of modulation of transcriptional activity promoted by a responsive nuclear receptor and a coactivator, which coactivator is the mentioned protein and is named COASTER, and which nuclear receptor is preferrably a steroid receptor.

L'invention concerne une protéine ayant une séquence d'acides aminés comme dans SEQ ID 7, 8, 11 ou 12, des protéines similaires, des variantes existant dans la nature et leurs équivalents fonctionnels homologues, ainsi que l'utilisation d'un polynucléotide codant pour une telle protéine, aux fins d'utilisation dans un essai et dans un procédé de modulation d'une activité transcriptionnelle favorisée par un récepteur nucléaire réactif répondant et un coactivateur. Ce coactivateur est la protéine mentionnée et est nommée COASTER, et ce récepteur nucléaire est, de préférence, un récepteur stéroïde.

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