C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
167/140, 167/37,
C12P 21/08 (2006.01) A61K 39/21 (2006.01) A61K 39/42 (2006.01) C07K 14/155 (2006.01) C07K 14/16 (2006.01) C07K 16/10 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2032505
The invention relates to an antigenic glycoprotein gp80 characterized by the following properties: it has a molecular weight (PM) close to 80 kDa; it is recognized by polyclonal antibodies directed against the glycoprotein gp300; it includes in association in the form a dimer to entities of the envelope transmembrane glycoprotein gp36, coded by the genome of a human retrovirus of the type HIV-2, susceptible of causing SLA or AIDS in human beings, or any glycoprotein having a molecular weight of the same order of magnitude, capable of forming an immunological complex of the type antigene-antibody, with antibodies directed against said gp80. The invention also relates to antibodies directed against said glycoprotein. It also relates to diagnostic and vaccination applications.
L'invention se rapporte à une glycoprotéine antigénique gp80 caractérisée par les propriétés sui- vantes: elle a un poids moléculaire (PM) voisin de 80 kDa; elle est reconnue par des anticorps polyclonaux dirigés contre la glycoprotéine gp300; elle comprend en association sous forme d'un dimère, deux entités de la glycoprotéine transmembranaire d'enveloppe gp36 codée par le génome d'un rétrovirus humain du type HIV-2, susceptible de provoquer un SLA ou un SIDA chez l'homme, ou toute glycoprotéine de poids moléculaire du même ordre de grandeur, capable de former un complexe immunologique du type antigène-anticorps, avec des anticorps dirigés contre ladite gp80.
Hovanessian Ara
Krust Bernard
Laurent Anne
Montagnier Luc
Rey Marie-Anne
Goudreau Gage Dubuc
Institut Pasteur
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