Coated capillary electrophoresis tubes and system

Details Coated capillary electrophoresis tubes and system Coated capillary electrophoresis tubes and system

G - Physics

01

N

G01N 27/447 (2006.01) B05D 5/12 (2006.01) G01N 27/26 (2006.01) G01N 27/453 (2006.01)

Patent

CA 2498001

The invention is directed to a capillary tube for electrophoresis that has a positively charged coating on the capillary inner surface that prevents positively charged analytes from adsorbing to the inner capillary surface. The capillary tube has an inner surface that is coated with a first polymer layer having a plurality of polymer groups comprising polyethylene imine, designated herein as (CH2CH2NH)x . The inner surface of the capillary typically has a second polymer layer covalently bonded to the first polymer layer. The invention includes a capillary tube where two or more than two polymer groups are covalently bonded to each other by a cross-linker. Also provided are an electrophoresis system the uses the coated capillary tubes, a method of performing electrophoresis that utilizes the coated capillary tubes, and a process for preparing the coated capillary tubes.

La présente invention concerne un capillaire pour électrophorèse dont la face interne est garnie d'un revêtement positivement chargé pour y empêcher l'adsorption des éléments à analyser positivement chargés. En l'occurrence, cette face interne du capillaire est garnie d'une 1?ère¿ couche polymère portant une pluralité de groupes polymères dont au moins une polyéthylène-imine, représentée ici par la formule (CH¿2?CH¿2?NH)¿x?. La face interne du capillaire est également généralement garnie d'une 2?ème¿ couche polymère liée par covalence à la 1?ère¿. L'invention inclut un capillaire dans lequel 2 groupes polymères au moins sont liés l'un à l'autre par covalence au moyen d'un réticulant. L'invention concerne également un système d'électrophorèse qui utilise ces capillaires intérieurement garnis, un procédé d'électrophorèse utilisant ces capillaires, et enfin un procédé permettant la réalisation de ces capillaires.

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