Coated medical devices and methods of making the same

Details Coated medical devices and methods of making the same Coated medical devices and methods of making the same

A - Human Necessities

61

L

A61L 27/34 (2006.01) A61L 27/54 (2006.01) A61L 29/08 (2006.01) A61L 29/16 (2006.01) A61L 31/10 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2636604

The present invention relates generally to coated medical devices, preferably a stent, that has a drug-eluting surface completely or partially coated with a coating that comprises two or more forms of a biologically active material. In particular, the invention is directed to a coated medical device having a coating that comprises at least one polymer and a biologically active material that is present in at least two different forms. The coating may include more than one coating layer. Preferably, the coating is capable of releasing the different forms of the biologically active material in different amounts, at different rates, and/or at different time periods. The invention also relates to methods of making and methods of using the coated medical device.

La présente invention concerne de manière générale des dispositifs médicaux à enrobage, de préférence un stent, pourvu d'une surface d'élution de médicament entièrement ou partiellement recouverte d'un enrobage contenant deux ou plusieurs formes d'un matériau actif d'un point de vue biologique. L'invention concerne en particulier un dispositif médical à enrobage formé d'un enrobage contenant au moins un polymère et un matériau actif d'un point de vue biologique présent sous au moins deux formes différentes. L'enrobage présente plus d'une couche d'enrobage. L'enrobage peut, de préférence, libérer les différentes formes du matériau actif d'un point de vue biologique en différentes quantités, à différentes vitesses, et/ou à différentes périodes temporelles. Linvention concerne également des procédés de fabrication et des procédés d'utilisation du dispositif médical à enrobage.

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