Coated medical devices for the treatment of vascular disease

Details Coated medical devices for the treatment of vascular disease Coated medical devices for the treatment of vascular disease

A - Human Necessities

61

F

A61F 2/06 (2006.01) A61B 17/22 (2006.01) A61L 27/44 (2006.01) A61L 27/54 (2006.01) A61M 25/10 (2006.01) A61M 29/00 (2006.01) A61M 37/00 (2006.01) A61P 7/00 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2425696

Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. In addition to reducing or substantially eliminating a biological organism's reaction to the introduction of the medical device to the organism, the medical device in combination with one or more therapeutic drugs, agents and/or compounds may be utilized to treat various vascular diseases, for example, restenosis and vulnerable plaque. In the case of vulnerable plaque, one or more drugs, agents or compounds may be utilized to treat the various aspects of vulnerable plaque and these drugs, agents and/or compounds may be released with a given release profile for the most effective treatment. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. 84

Les dispositifs médicaux, et en particulier, les dispositifs implantables, peuvent être recouverts afin de réduire ou d'éliminer considérablement la réaction d'un organisme biologique à l'insertion de celui-ci. Les dispositifs médicaux peuvent être recouverts d'une matière biocompatible de plusieurs types. Des médicaments, des agents ou des composés peuvent être mélangés à la matière biocompatible et fixés à au moins une partie du dispositif. Outre la réduction ou la presque élimination de la réaction de l'organisme biologique à l'introduction du dispositif dans ce dernier, le dispositif en association avec un ou plusieurs médicaments, agents et/ou composés peut servir à traiter diverses maladies vasculaires, par exemple, la resténose et la présence de plaques vulnérables. Dans le cas des plaques vulnérables, un ou plusieurs médicaments, agents ou composés peuvent servir à traiter divers aspects des plaques vulnérables et ces médicaments, agents et/ou composés peuvent être libérés en fonction d'un profil de libération donné pour obtenir le traitement le plus efficace. Diverses matières et méthodes d'enrobage peuvent être utilisées pour conserver les médicaments, agents ou composés sur le dispositif médical jusqu'à ce qu'il soit inséré et bien placé.

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