Coated oral nicotine formulation buffered with amino acid

Details Coated oral nicotine formulation buffered with amino acid Coated oral nicotine formulation buffered with amino acid

A - Human Necessities

61

K

A61K 47/18 (2006.01) A24B 15/16 (2006.01) A61K 9/20 (2006.01) A61K 9/68 (2006.01) A61K 31/465 (2006.01) A61P 25/34 (2006.01)

Patent

CA 2685456

Coated oral dosage forms for the delivery of nicotine in any form to a subject by rapid intraoral delivery of nicotine comprising at least one core, nicotine in any form and/or a nicotine mimicking agent, at least one coating layer and optionally at least one or more other additives, wherein said at last one coating layer is buffered, whereby is used at least one amino acid as buffering agent. Also contemplated are a method for the delivery of nicotine in any form, a method for the reduction of the urge to smoke or use tobacco as well as a method for producing said coated product and use of the same for obtaining a rapid intraoral uptake of nicotine.

L'invention concerne des formes posologiques orales enrobées destinées à l'administration de nicotine à un sujet, sous une forme quelconque, par administration intraorale rapide de nicotine. Ces formes posologiques comprennent au moins un noyau, de la nicotine sous une forme quelconque et/ou agent imitant la nicotine, au moins une couche d'enrobage et, éventuellement, au moins un ou plusieurs additifs, ladite couche d'enrobage étant tamponnée avec au moins un acide aminé. L'invention concerne en outre une méthode d'administration orale de nicotine sous une forme quelconque; une méthode de réduction de l'envie impérieux de fumer ou de l'usage du tabac; ainsi qu'une méthode de production du produit enrobé et son utilisation aux fins d'obtenir une absorption intraorale rapide de nicotine.

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