A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61K 31/403 (2006.01)
Patent
CA 2560812
A coated tablet formulation is provided which includes a medicament such as the PPAR / dual agonist peliglitazar or muraglitazar. The coated tablet includes a tablet core containing one or more fillers, one or more binders, one or more disintegrants, and other conventional excipients, and a coating on the tablet core, which coating may include one or more layers, at least one layer of which is formed of medicament and one or more coating polymers, preferably a hydroxypropylmethyl cellulose based polymer. A method for forming the coated tablet via a spray-dried coating technique is also provided.
La présente invention a trait à une formulation de comprimé enrobé comportant un médicament tels que le peliglitazar ou muraglitazar double agoniste des PPAR .alpha./.gamma.. Le comprimé enrobé comporte un noyau de comprimé contenant une ou des charges, un ou des liants, un ou des désintégrants, et d'autres excipients classiques, et un enrobage sur le noyau de comprimé, ledit enrobage pouvant inclure une ou plusieurs couches, au moins une couche qui est formée de médicament et d'une ou de plusieurs polymères d'enrobage, de préférence du polymère à base de d'hydroxypropylméthyle cellulose. L'invention a également trait à un procédé pour la formation du comprimé enrobé grâce à une technique d'enrobage de séchage par pulvérisation.
Desai Divyakant
Li Danping
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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