Coating compositions for bioactive agents

Details Coating compositions for bioactive agents Coating compositions for bioactive agents

A - Human Necessities

61

L

A61L 29/08 (2006.01) A61L 31/10 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2563150

A coating composition and related method for use in applying a bioactive agent to a surface in a manner that will permit the bioactive agent to be released from the coating in vivo. The composition is particularly well suited for coating the surface of implantable medical device, such as a stent or catheter, in order to permit the device to release bioactive agent to the surrounding tissue over time. The composition includes a plurality of compatible polymers having different properties that can permit them to be combined together to provide an optimal combination of such properties as durability, biocompatibility, and release kinetics.

L'invention concerne une composition de revêtement et un procédé associé destinés à être utilisés dans l'application d'un agent bioactif à une surface d'une manière permettant la libération de l'agent bioactif du revêtement <i>in vivo</i>. La composition est particulièrement bien adaptée au revêtement de la surface d'un dispositif médical implantable tel qu'un stent ou un cathéter, afin de permettre au dispositif de libérer l'agent bioactif vers le tissu environnant, dans le temps. La composition contient une pluralité de polymères compatibles ayant différentes propriétés leur permettant d'être combinés ensemble pour donner une combinaison optimale de propriétés telles que la durabilité, la biocompatibilité et la cinétique de libération.

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