Coating for bioprosthetic device and method of making same

Details Coating for bioprosthetic device and method of making same Coating for bioprosthetic device and method of making same

A - Human Necessities

61

L

167/327

A61L 27/00 (2006.01)

Patent

CA 1209051

ABSTRACT COATING FOR BIOPROSTHETIC DEVICE AND METHOD OF MAKING SAME A coating and integral treatment for improv- ing the biophysical stability of bioprosthetic devices after implantation, particularly with respect to cal- cification, and, specifically, a method for treating animal tissues, such as heart valves, to provide improved biophysical stability in allograft and heter- ograft transplantations. The increased stability results, in-part, from the creation of a three-dimen- sional matrix of a primary strucutral component of the prosthetic device and covalently attached calcifica- tion inhibitors. Other materials, some having addi- tional stabilizing effects, may be utilized to form additional bridges or fill the interstitial gaps in the matrix. After implantation, the resultant modi- fied device exhibits minimal surface for intramatrix growth of calcium phosphate crystals, and additional- ly, may inhibit platelet aggregation, enzymatic degra- dation and host rejection, while minimizing the risk of mechanical failure, in the host organism.

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