Coating having polymerized silane derivatives for medical...

Details Coating having polymerized silane derivatives for medical... Coating having polymerized silane derivatives for medical...

A - Human Necessities

61

L

A61L 31/06 (2006.01) A61L 31/10 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2476431

Coatings are provided in which surfaces may be activated by covalently bonding a silane derivative (A) to the metal surface, covalently bonding a lactone polymer (B) to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester (C) on the bonded lactone. Biologically active agents may be deposited with the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents.

L'invention concerne des revêtements qui comportent des surfaces pouvant être activées par : liaison covalente d'un dérivé de silane (A) avec une surface métallique, liaison covalente d'un polymère de lactone (B) avec le dérivé de silane par polymérisation in situ par ouverture de cycles, et dépôt d'au moins une couche polyester (C) sur la lactone liée. Des agents biologiquement actifs peuvent être déposés avec les couches polyester. Ces surfaces revêtues peuvent être utiles dans des dispositifs médicaux, en particulier des endoprothèses.

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