Coating system

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/28 (2006.01)

Patent

CA 2367669

The present invention provides a coating system for solid pharmaceutical dosage units, such as tablets. The coating system comprising (a) a subcoat; (b) an optional colorcoat; and (c) a polish coat. In a preferred embodiment, the present invention provides (a) a subcoat comprising (i) hydroxypropyl methylcellulose (HPMC) and (ii) a polysaccharide; (b) a colorcoat comprising (i) a colorant and (ii) a polysaccharide which may be the same as or different from the polysaccharide of the subcoat; and (c) a polish coat comprising (i) a polyethylene glycol and, optionally, (ii) a wax. Also disclosed is a method for providing gloss to a coated pharmaceutical solid dosage unit by coating a pharmaceutical core with the aforementioned polish coat.

Cette invention concerne un système d'enrobage pour des médicaments solides tels que des dragées. L'ensemble d'enrobage comprend (a) une sous-couche ; (b) éventuellement une couche colorée et ; (c) une couche de glaçage. Selon un mode de réalisation préférée, la sous-couche (à) comprend (i) un hydroxypropyl méthylcellulose (HPMC) et (ii) un polysaccharide; la couche colorée comprend (i) un colorant et (ii) un polysaccharide qui peut être ou ne pas être le même identique ou non à celui de la sous-couche ; et la couche de glaçage (c) comprend (i) un polyéthylène glycol et, éventuellement, (ii) une cire. L'invention concerne également un procédé de satinage permettant de donner un aspect satiné à un médicament sous forme solide au moyen du produit de glaçage susmentionné.

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