Coatings for implantable medical devices for liposome delivery

Details Coatings for implantable medical devices for liposome delivery Coatings for implantable medical devices for liposome delivery

A - Human Necessities

61

L

A61L 31/08 (2006.01) A61K 9/00 (2006.01) A61K 9/127 (2006.01) A61L 27/28 (2006.01) A61L 27/54 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2710284

Disclosed herein are medical devices, such as implantable devices (e g stents), comprising at least one coating covering at least a portion of the device in the form of film. The film may be a dry film and comprise at least one lipid bilayer and at least one pharmaceutically effective agent. Alternatively, the film may comprise at least one lipid, not necessarily in bilayer form, and at least one pharmaceutically effective agent. When the devices comprising the at least one lipid bilayer are exposed to an aqueous fluid, liposomes are released, encapsulating the pharmaceutically effective agent. The coatings may be placed directly on the device, or applied to a substrate attached to the device.

L'invention concerne des dispositifs médicaux, tels que des dispositifs médicaux implantables (par exemple, des stents), comprenant au moins un revêtement recouvrant au moins une partie du dispositif sous forme de film. Le film peut être un film sec et il comprend au moins une bicouche lipidique et au moins un agent pharmaceutiquement efficace. Selon une autre variante, le film peut comprendre au moins un lipide, non nécessairement sous forme de bicouche, et au moins un agent pharmaceutiquement efficace. Lorsque les dispositifs comprenant la bicouche lipidique sont exposés à un fluide aqueux, des liposomes sont libérés, ce qui encapsule ledit agent pharmaceutiquement efficace. Les revêtement peuvent être directement placés sur le dispositif ou appliqués sur un substrat rattaché au dispositif.

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