Cobalt schiff base compounds

Details Cobalt schiff base compounds Cobalt schiff base compounds

C - Chemistry, Metallurgy

07

F

C07F 15/06 (2006.01) A61K 31/295 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) C07H 23/00 (2006.01) C07K 2/00 (2006.01) C07K 7/06 (2006.01) C12N 9/99 (2006.01)

Patent

CA 2240183

The invention relates to cobalt compounds in which divalent or trivalent cobalt is complexed with water soluble tetradentate Schiff's bases. The tetradentate Schiff's bases preferably contain two nitrogen atoms and two oxygen atoms as coordinating atoms. The compounds can contain polypeptide or nucleic acid targeting moities and can be used to inhibit enzymes such as thrombin and to inhibit zinc finger proteins.

L'invention se rapporte à des composés de cobalt dans lesquels le cobalt divalent ou trivalent est complexé avec des bases de Schiff tétradentées solubles dans l'eau. Les bases de Schiff tétradentées contiennent de préférence deux atomes d'azote et deux atomes d'oxygène jouant le rôle d'atomes de coordination. Ces composés peuvent contenir des fractions de ciblage de polypeptides ou d'acide nucléique et peuvent être utilisés pour inhiber des enzymes telles que la thrombine et des protéines à doigts de zinc.

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