Cocaethylene immunogens and antibodies

Details Cocaethylene immunogens and antibodies Cocaethylene immunogens and antibodies

A - Human Necessities

61

K

A61K 38/00 (2006.01) C07D 451/04 (2006.01) C07D 451/06 (2006.01) C07K 1/00 (2006.01) C07K 16/00 (2006.01) C07K 16/16 (2006.01) C09B 47/04 (2006.01) C12N 9/96 (2006.01) G01N 33/53 (2006.01) G01N 33/531 (2006.01) G01N 33/94 (2006.01)

Patent

CA 2284613

The ethyl ester of derivatives of benzoyl ecgonine are provided having a linking group at the para position of the benzoyl group. The derivatives are used to bond to immunogenic polypeptides for production of antisera and monoclonal antibodies. The antisera and antibodies find use in assays, for treatment of cocaine overdoseand detoxification.

La présente invention concerne l'ester éthylique de dérivés de benzoylecgonine présentant un groupe de liaison à la position para du groupe benzoylique. On utilise les dérivés de manière à produire une liaison avec des polypeptides immunogènes pour obtenir des antisérums et des anticorps monoclonaux. On utilise également les antisérums et les anticorps dans des analyses, pour le traitement de la surdose de cocaïne et de détoxication.

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