Cocaine receptor binding ligands

Details Cocaine receptor binding ligands Cocaine receptor binding ligands

C - Chemistry, Metallurgy

07

D

C07D 451/02 (2006.01) A61K 31/46 (2006.01)

Patent

CA 2263961

The invention relates to novel compounds of formula (I): (see formula I) which show high affinity for cocaine receptors in the brain, particularly dopamine and serotonin transporter sites. The compounds may be used as imaging or pharmaceutical agents, in the diagnosis and treatment of drug addiction, depression, anorexia and neurodegenerative diseases.

L'invention concerne de nouveaux composés qui manifestent une forte affinité pour des récepteurs de cocaïne dans le cerveau, en particulier des sites transporteurs de dopamine et de sérotonine. Lesdits composés peuvent être utilisés comme agents de formation d'images ou comme agents thérapeutiques ainsi que dans le diagnostic et le traitement de la toxicomanie, de la dépression, de l'anorexie et de maladies neurodégénératives.

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