A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/129
A61K 39/012 (2006.01) C07K 14/455 (2006.01) A61K 39/00 (2006.01)
Patent
CA 1270758
2303P/0009A 17140 COCCIDIOSIS VACCINE ABSTRACT OF THE DISCLOSURE Sporozoites of coccidia fail to develop in chickens which are immune and many are blocked from penetrating host cells. Although previous attempts to immunize chickens with non-viable coccidial antigens have been unsuccessful it has been discovered that extracts from sporozoites or sporulated oocysts of E. tenella induce high levels of protective immunity. These extracts contain at least 15 polypeptides many of which are associated with the surface of the sporozoite and induce good immune responses. Antibody to these polypeptides blocks sporozoite-host cell penetration in vitro and neutralizes sporozoites in vivo. One or more of these polypeptides may be used as an antigen to protect against coccidiosis.
484494
Galuska Stefan
Murray Peter K.
Galuska Stefan
Goudreau Gage Dubuc
Merck & Co. Inc.
Murray Peter K.
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