Cocrystal of c-glycoside derivative and l-proline

Details Cocrystal of c-glycoside derivative and l-proline Cocrystal of c-glycoside derivative and l-proline

C - Chemistry, Metallurgy

07

D

C07D 407/10 (2006.01) A61K 31/381 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2649022

A cocrystal of (1S)-1,5-anhydro-1-[3-(1-benzothien-2-ylmethyl)-4-fluorophenyl]-D-glucitol and L-proline. This cocrystal ensures a constant quality, excelling in storage stability, and does not exhibit any moisture absorptivity, being a cocrystal of known compound (A) being suitable as a crystal of raw drug to be finished into pharmaceutical products.

La présente invention concerne un cocristal de (1S)-1,5-anhydro-1-[3-(1-benzothien-2-ylméthyl)-4-fluorophényl]-D-glucitol et de L-proline. Ce cocristal assure une qualité constante, avec une excellente stabilité de conservation, et ne présente aucune absorption d'humidité. Il s'agit d'un cocristal d'un composé connu (A) convenant en tant que cristal d'une drogue destinée à être finie en produits pharmaceutiques.

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